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mycobacterial sulfolipid biosynthesis

State Icon Reaction EC-Number Confidence maximal confidence score from EnzymeDetector
3''-phosphoadenylyl-sulfate + trehalose <=> adenosine_3,5''-bisphosphate + 2-O-sulfo-alpha,alpha-trehalose + H+ 2.8.2.37 trehalose 2-sulfotransferase
2.8.2.8 [heparan sulfate]-glucosamine N-sulfotransferase


C37-hydroxyphthioceranyl-[(hydroxy)phthioceranate_synthase] + 2''-palmitoyl-2-O-sulfo-alpha,alpha-trehalose <=> SL1278 + a_holo-[(hydroxy)phthioceranic_acid_synthase] 2.3.1.283 2'-acyl-2-O-sulfo-trehalose (hydroxy)phthioceranyltransferase

palmitoyl-[acyl-carrier_protein] + CoA <=> palmitoyl-CoA + [acyl-carrier_protein] 2.3.1
2.3.1.85 fatty-acid synthase system
2.3.1.86 fatty-acyl-CoA synthase system



a_palmitoyl-[(hydroxy)phthioceranic_acid_synthase] + (S)-methylmalonyl-CoA + NADPH + H+ <=> C37-hydroxyphthioceranyl-[(hydroxy)phthioceranate_synthase] + CoA + CO2 + NADP+ + H2O 2.3.1.287 phthioceranic/hydroxyphthioceranic acid synthase

SL1278 <=> sulfolipid-2 + 2''-palmitoyl-2-O-sulfo-alpha,alpha-trehalose 2.3.1.284 3'-(hydroxy)phthioceranyl-2'-palmitoyl(stearoyl)-2-O-sulfo-trehalose (hydroxy)phthioceranyltransferase

palmitoyl-CoA + 2-O-sulfo-alpha,alpha-trehalose <=> 2''-palmitoyl-2-O-sulfo-alpha,alpha-trehalose + CoA 2.3.1.288 2-O-sulfo trehalose long-chain-acyltransferase

a_long-chain_acyl-adenylate_ester + a_holo-[(hydroxy)phthioceranic_acid_synthase] <=> a_palmitoyl-[(hydroxy)phthioceranic_acid_synthase] + AMP + H+ 6.2.1.57 long-chain fatty acid adenylase/transferase FadD23

palmitate + ATP + H+ <=> a_long-chain_acyl-adenylate_ester + diphosphate 6.2.1.49 long-chain fatty acid adenylyltransferase FadD28
6.2.1.57 long-chain fatty acid adenylase/transferase FadD23


palmitoyl-[acyl-carrier_protein] + H2O <=> fatty_acid + [acyl-carrier_protein] + H+ 2.3.1.85 fatty-acid synthase system
3.1.2.14 oleoyl-[acyl-carrier-protein] hydrolase
3.1.2.21 dodecanoyl-[acyl-carrier-protein] hydrolase



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